Quick Mass Determination

Compact Mass Spectrometer (ESI, APCI/TLC/MS), Advion, USA.

Mass spectrometry’s characteristics have raised it to an outstanding position among analytical methods: unequalled sensitivity, detection limits, speed and diversity of its applications. Most applications are oriented to proteomic, metabolomic studies, drug discovery and metabolism. In addition to other applications such as pollution control, food analysis and forensic medicine.

Specifications

Advion compact mass spectrometer (CMS) is provided with the following specification:

• Ion Source: ESI, APCI, or APCI/ASAP
• Polarity: Positive & negative ion switching in a single analysis
• Flow Rate Range: 
  • ESI: 10 µL/min to 1 mL/min
  • APCI: 10 µL/min to 2 mL/min
• m/z Range:
  • expression S m/z 10 to 1,200
  • expression L m/z 10 to 2,000
• Acquisition Speed: 10,000 m/z units/sec
• Sensitivity (ESI): 10 pg reserpine (FIA – 5 µL injection at 100 µL/min) 100:1 S/N (RMS) with SIM of m/z 609.3
• Accuracy: ±0.1 m/z units of the entire acquisition range
• Stability: 0.1 m/z units at m/z 1,200 over 12 hour period operating temperature of 20ºC ±1ºC
• Polarity Switching Speed: 50 ms
• Dynamic Range: 4.5 orders of magnitude

Applications

The expression CMS integrates with almost every chemistry method from the simplest, fastest direct probe analysis needing no sample preparation to ultra-high-performance compound separation with LC integration. The expression CMS offers the most versatile sample methods on the market, including/ but not limited to:

Reaction Monitoring

• Compound identification for batch and flow chemistry
• Confirm identity and purity quickly and accurately

Monitoring of metabolites

• Preliminary screening and prioritization of plant extracts through detection of major constituents (confirmation of proposed identity)
• Detection of metabolites in biotransformation and microbial transformation of drugs
• Detection of degradation products of drugs.

Available injection Interfaces

• TLC
• ASAP (Probe) available only with ACPI mode
• Direct injection

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