Improving the efficiency of antiviral compounds represents a crucial step in developing alternative strategies, but this depends on a better understanding of their mode of action. Sample with potent IC50 can target IAV at 3 main compartments; cell-free status “viricidal effect”, adsorption interference and/or during viral replication.

For each test compound, the following mechanisms are tested using Plaque Reduction Assay:

1. Viral adsorption inhibition
2. Viral replication inhibition
3. Direct virucidal effect

• Results will be provided as viral inhibition percent for the three main tested steps (Adsorption, replication and viricidal effect)