Moisture content by Karl Fischer method

1. Scope

• Moisture content by Karl Fischer (USP method 1a) for pharmaceutical substances.

2. Introduction

2.1-What is Karl Fischer method?

• It is titrimetric determination of water based upon the quantitative reaction of water with an anhydrous solution of sulfur dioxide and iodine in the presence of a buffer that reacts with hydrogen ions.

3. Procedure of measurement

• ISO17025 certified method.

4. Proposed service price

• 300 LE X no. of solvents analyzed

5. References

• United States Pharmacopeia (USP) 43: online version. General Chapter 281. Residue on Ignition

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