Animal Studies
Histopathologic examination
EGP0.00Histopathologic examination of whole-body organs
Histopathology refers to the microscopic examination of tissue by an expert pathologist in order to study the manifestations of a disease or toxicity. Following experimentation on animals, a histopathologic check can reveal a wide range of insights on different effects that took place on animal organs.
Our services include
- Organ harvest.
- Tissue fixation in paraffin
- Processing and sections preparation
- Staining
- Pathological check by experts in the field
- Interpretation and detailed report with high-quality images
Our list of checks include:
- All gross lesions • Heart •Pancreas • Stomach (forestomach, glandular stomach)
- Adrenal gland • Ileum •Jejunum •Parathyroid gland •Teeth
- Aorta •Peripheral nerves • Testis • kidney • pituitary gland • Thymus
- Brain (including sections of cerebrum, cerebellum, and medulla/pons)
- Caecum • Lacrimal gland (exorbital) • Prostate • Thyroid • Cervix
- Liver • Rectum • Tongue • Lung • Salivary gland • Trachea • Skin
- Colon • Lymph nodes (both superficial and deep) • Urinary bladder
- Seminal vesicle • Mammary gland • Skeletal muscles • uterus (including cervix)
- Upper respiratory tract, including nose, turbinates, and paranasal sinuses
- Eye (including retina) • Oesophagus • Urethra • Ovary
- Spinal cord (at three levels: cervical, mid-thoracic, and lumbar)
- Femur with joint • Olfactory bulb • Spleen • Vagina
- Sections of bone marrow and/or a fresh bone marrow aspirate
Service Pricing
Price is determined on a case-by-case basis according to the required experimental study.
Interested in animal experiments? Click here
Pharmacokinetic studies in animals
EGP0.00Preclinical pharmacokinetic studies in animals
Pharmacokinetics (PK) describes everything that the body does to the drug after administration and includes absorption, distribution, metabolism, and excretion. Pharmacokinetic studies are an essential part of the drug development process. Understanding the pharmacokinetic and pharmacodynamic behavior of a given therapeutic drug is an essential element of understanding its effectiveness and safety, as well as identifying the proper dosage and distribution. PK studies can be carried for the drug molecule alone or for the whole dosage form.
Experimental designs
- Available animal models: rats & mice.
- We have the necessary expertise in the following routes of administration:
- Oral
- IP
- SC
- IV (only in rats)
Available tests
- Collecting blood samples (plasma on EDTA & citrate, as well as serum).
- Drug quantification using LC-MS
- Whole aorta extraction
- Extraction of hippocampus and frontal cortex
- Fetal double staining for bone and cartilage
- Complete semen analysis
- Urine collection and analysis
- Mammalian bone marrow chromosome aberration test
- Mammalian erythrocyte micronucleus test
- Gross necropsy examination
Service Pricing
Price is determined on a case-by-case basis according to the required experimental study.