nano drug delivery systems
Determination of Isoelectric point
EGP1,000.00The isoelectric point (pI) is the pH of a solution at which the net charge of a zwitterion molecule (e.g. amino acids, peptides, proteins) becomes zero. At solution pH that is above the pI, the surface of the molecule is predominantly negatively charged, while it becomes positively charged when the solution pH is lower than the pI.
Identifying the isoelectric point of your molecule can help in several ways:
- For protein purification, where proteins have minimal water solubility at their pI.
- Study the best level of outer charge for your application
Preparation of Nano Drug Delivery Systems
Owing to the rapid development of nanoscience and outstanding performance of nanomaterials, nanotechnology has become a new solution to overcome the limitations of traditional dosage forms. Nano-drug delivery systems (NDDSs) are a class of nanomaterials that have abilities to increase the stability and water solubility of drugs, prolong the cycle time, increase the uptake rate of target cells or tissues, and reduce enzyme degradation, thereby improve the safety and effectiveness of drugs. NDDSs can be administered by various routes including inhalation, oral administration, or intravenous injection, remaining better bioavailability.